Journal article
Germline HOXB13 p.Gly84Glu mutation and risk of colorectal cancer
MR Akbari, LN Anderson, DD Buchanan, M Clendenning, MA Jenkins, AK Win, JL Hopper, GG Giles, R Nam, S Narod, S Gallinger, SP Cleary
Cancer Epidemiology | ELSEVIER SCI LTD | Published : 2013
Abstract
Introduction: The HOXB13 pGly84Glu mutation has recently been associated with an increased risk of prostate cancer but the association of other cancer sites with this allele has not been assessed. Data has suggested that HOXB13 expression levels are decreased in colorectal cancer (CRC) cell lines indicating this gene may be involved in colorectal tumourigenesis. Methods: To evaluate a potential association of this mutation with CRC, we genotyped the mutation in 2695 CRC cases and 4593 controls from population-based registries in Canada and Australia. Results: The HOXB13 pGly84Glu mutation was more common in CRC cases than controls (0.48% vs. 0.17%, P = 0.02) indicating a significant associat..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the National Cancer Institute, National Institutes of Health under RFA # CA-95-011, the Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783), the Australasian Colorectal Cancer Family Registry (U01 CA097735), and through cooperative agreements with members of the Colon Cancer Family Registry (CFRs) and P.I.s. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the CFRs, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the CFR.